KAT7

Description

The KAT7 (lysine acetyltransferase 7) is a protein-coding gene located on chromosome 17.

KAT-7 is a radio telescope located in the Meerkat National Park, South Africa. It served as a test bed for the larger MeerKAT telescope and was used to demonstrate technology for South Africa's bid to host the Square Kilometre Array. It is the first radio telescope built with a composite reflector and uses a Stirling pump for cryogenic cooling. KAT-7 consists of 7 dishes, each 12 meters in diameter, and was able to produce its first interferometric image in April 2010. In December 2010, a successful detection of very long baseline interferometry (VLBI) fringes was achieved between the Hartebeesthoek Radio Astronomy Observatory's 26-meter dish and one of the KAT-7 dishes.

KAT7/HBO1 is a histone acetyltransferase that plays a crucial role in various cellular processes. It specifically acetylates histone H3 at Lys-14 (H3K14ac) and histone H4 at Lys-5, Lys-8, and Lys-12 (H4K5ac, H4K8ac, and H4K12ac, respectively). The acetylation of histone H3 at Lys-14 is essential for various processes, including gene transcription, protein ubiquitination, immune regulation, stem cell maintenance, and embryonic development. The acetylation of histone H4 plays a role in DNA replication initiation. KAT7/HBO1 forms complexes with various scaffold subunits, such as BRPF and JADE, which determine the specificity of its acetylation activity. BRPF-containing complexes target histone H3, while JADE-containing complexes target histone H4. KAT7/HBO1 is also involved in nucleotide excision repair, where it mediates histone acetylation to facilitate the recruitment of XPC to damaged DNA sites. Furthermore, KAT7/HBO1 can act as an inhibitor of NF-κB independently of its histone acetyltransferase activity. KAT7/HBO1 also plays a central role in the maintenance of leukemia stem cells by facilitating the high expression of key genes such as HOXA9 and HOXA10. KAT7/HBO1 interacts with various proteins, including MCM2, ORC1, the androgen receptor, CDT1, MAP2K1, CUL1, p53/TP53, and MIS18BP1, which suggests its involvement in a complex network of cellular interactions.

KAT7 is also known as HBO1, HBOA, MYST2, ZC2HC7.

Associated Diseases

WES Whole Exome Sequencing