JUNB

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Description

The JUNB (JunB proto-oncogene, AP-1 transcription factor subunit) is a protein-coding gene located on chromosome 19.

JUNB is a human protein encoded by the JUNB gene. It functions as a transcription factor, regulating gene activity after the initial response to growth factors. JUNB binds to the DNA sequence 5'-TGA[CG]TCA-3'. JUNB interacts with BRCA1 and SMAD3.

JUNB plays a role in regulating gene activity in response to growth factors. It binds to a specific DNA sequence (5'-TGA[GC]TCA-3') and forms a complex with proteins from the FOS family, known as AP-1. This complex enhances JUNB's ability to bind to DNA and activate gene transcription.

JUNB is also known as AP-1.

Associated Diseases

• thyroid gland adenocarcinoma
• esophageal cancer
• glycoprotein storage disease
• hemoglobin H disease
• hemoglobin C-beta-thalassemia syndrome
• isolated spina bifida
• combined immunodeficiency due to OX40 deficiency
• spina bifida-hypospadias syndrome
• dominant beta-thalassemia
• muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type a, 10
• anencephaly 1
• hemolytic anemia due to diphosphoglycerate mutase deficiency