JTB
Description
The JTB (jumping translocation breakpoint) is a protein-coding gene located on chromosome 1.
JTB may refer to:
JTB is required for normal cytokinesis during mitosis. It plays a role in the regulation of cell proliferation and may be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere, ensuring correct chromosome alignment and segregation. It is also required for chromatin-induced microtubule stabilization and spindle assembly. JTB increases AURKB activity and inhibits apoptosis induced by TGFB1. Overexpression of JTB induces swelling of mitochondria and reduces mitochondrial membrane potential.
JTB is also known as HJTB, HSPC222, PAR, hJT.
Associated Diseases
- acroleukopathy, symmetric
- familial progressive hyperpigmentation
- hyperpigmentation with or without hypopigmentation, familial progressive
- homocarnosinosis
- exudative vitreoretinopathy 2, X-linked
- prostate cancer
- cancer
- breast cancer
