JDP2
Description
The JDP2 (Jun dimerization protein 2) is a protein-coding gene located on chromosome 14.
JDP2, also known as Jun dimerization protein 2, is a protein encoded by the JDP2 gene in humans. It belongs to the AP-1 family of transcription factors. JDP2 was discovered to dimerize with c-Jun and suppress AP-1-mediated activation using a Sos-recruitment system. Subsequently, the yeast-two hybrid system revealed that JDP2 binds to activating transcription factor 2 (ATF2) to repress ATF-mediated transcriptional activation. JDP2 regulates transcription dependent on both TPA response element (TRE) and cAMP-responsive element (CRE). The JDP2 gene resides on human chromosome 14q24.3 (46.4 kb, 75,427,715 bp to 75,474,111 bp) and mouse chromosome 12 (39 kb, 85,599,105 bp to 85,639,878 bp), located about 250 kbp within the Fos-JDP2-BATF locus. Alternative splicing of JDP2 produces at least two isoforms. The protein JDP2, containing 163 amino acids, belongs to the basic leucine zipper (bZIP) family and exhibits high homology with the ATF3 bZIP domain. The bZIP domain encompasses amino acids from position 72 to 135, the basic motif from position 74 to 96, and the leucine zipper from 100 to 128. The canonical JDP2 has a molecular weight of 18,704 Da.
JDP2, as part of the AP-1 transcription factor complex, inhibits transactivation initiated by the Jun family of proteins. This protein plays a role in various transcriptional responses linked to AP-1, including UV-induced apoptosis, cell differentiation, and both tumorigenesis and its suppression. JDP2 can act as a repressor by recruiting histone deacetylase 3 (HDAC3) to the promoter region of JUN. It likely influences transcription by directly regulating histone modifications and chromatin assembly.
JDP2 is also known as JUNDM2.
Associated Diseases
- cancer
- autosomal recessive osteopetrosis 6
- Eiken syndrome
- osteosclerosis-ichthyosis-premature ovarian failure syndrome
