IVNS1ABP
Description
The IVNS1ABP (influenza virus NS1A binding protein) is a protein-coding gene located on chromosome 1.
The IVNS1ABP gene, located on human chromosome 19, encodes the influenza virus NS1A-binding protein. This protein is involved in various cellular processes, including pre-mRNA splicing, the aryl hydrocarbon receptor (AHR) pathway, F-actin organization, and protein ubiquitination.
The IVNS1ABP gene encodes a protein involved in various cellular processes, including pre-mRNA splicing, the aryl hydrocarbon receptor (AHR) pathway, F-actin organization, and protein ubiquitination. It contributes to the dynamic organization of the actin skeleton by stabilizing actin filaments through its Kelch repeats, protecting cells from actin destabilization-induced cell death. IVNS1ABP acts as a modifier in the AHR pathway, increasing the availability of AHR for transcription activation. Additionally, it functions as a negative regulator of the BCR(KLHL20) E3 ubiquitin ligase complex, preventing the ubiquitin-mediated proteolysis of PML and DAPK1, two tumor suppressors. It inhibits pre-mRNA splicing in vitro.
IVNS1ABP is also known as ARA3, FLARA3, HSPC068, IMD70, KLHL39, ND1, NS-1, NS1-BP, NS1BP.
