ITPR3
Description
The ITPR3 (inositol 1,4,5-trisphosphate receptor type 3) is a protein-coding gene located on chromosome 6.
ITPR3, also known as inositol 1,4,5-trisphosphate receptor, type 3, is a protein that acts as both a receptor for IP3 and a calcium channel. It plays a critical role in taste perception, specifically in the detection of sweet, bitter, and umami flavors. When IP3 binds to ITPR3, it triggers the release of calcium from the ER, which activates TRPM5, a channel involved in taste transduction. This activation leads to depolarization and the generation of action potentials, ultimately contributing to the perception of taste.
ITPR3 is a receptor for inositol 1,4,5-trisphosphate (IP3), a signaling molecule that triggers the release of calcium from intracellular stores. It plays a critical role in maintaining calcium balance within cells.
ITPR3 is also known as CMT1J, IP3R, IP3R3.
