ITPK1
Description
The ITPK1 (inositol-tetrakisphosphate 1-kinase) is a protein-coding gene located on chromosome 14.
ITPK1 (Inositol-tetrakisphosphate 1-kinase) is an enzyme that in humans is encoded by the ITPK1 gene. It is involved in inositol signaling pathways which regulate the conductance of calcium-activated chloride channels, and therefore could be relevant in the study of cystic fibrosis.
ITPK1 is a kinase that can phosphorylate various inositol polyphosphates, including Ins(3,4,5,6)P4 and Ins(1,3,4)P3. It phosphorylates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5, a reaction thought to be important for regulating calcium-activated chloride channels. ITPK1 also phosphorylates Ins(1,3,4)P3 to form Ins(1,3,4,6)P4, a key molecule in the InsP6 pathway. ITPK1 can also act as a phosphatase, dephosphorylating Ins(1,3,4,5)P4, Ins(1,3,4,6)P4, and Ins(1,3,4,5,6)P5. It may also act as an isomerase, interconverting Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4. ITPK1 is likely the rate-limiting enzyme of the InsP6 pathway and plays a role in modifying TNF-alpha-induced apoptosis and in MLKL-mediated necroptosis. It produces highly phosphorylated inositol phosphates, such as InsP6, which bind to MLKL, leading to its activation and localization to the cell membrane during necroptosis.
ITPK1 is also known as ITRPK1.
