ITIH2
Description
The ITIH2 (inter-alpha-trypsin inhibitor heavy chain 2) is a protein-coding gene located on chromosome 10.
Inter-alpha-trypsin inhibitor heavy chain H2 (ITIH2) is a protein encoded by the ITIH2 gene in humans. It contains a Gla domain, indicating a dependence on vitamin K for its production through post-translational modification. Its function likely relies on calcium ions.
ITIH2 plays a crucial role in regulating hyaluronan (HA) levels and distribution within the body. It acts as a carrier protein for HA in serum, transporting it throughout the circulatory system. Additionally, ITIH2 acts as a bridge between HA and other matrix proteins, including those found on cell surfaces. By connecting these components, ITIH2 helps regulate the localization, synthesis, and degradation of HA, all of which are essential for various cellular processes.
ITIH2 is also known as H2P, ITI-HC2, SHAP.
