ITGB7

Description

The ITGB7 (integrin subunit beta 7) is a protein-coding gene located on chromosome 12.

Integrin beta-7 (ITGB7) is a protein involved in cell adhesion and signaling. It is encoded by the ITGB7 gene in humans. ITGB7 forms heterodimers with alpha subunits of integrins, specifically ITGA4 (alpha-4) and ITGAE (alpha-E), creating distinct receptors with different functions. The ITGA4/ITGB7 heterodimer forms the α4β7 integrin receptor, also known as LPAM-1, which plays a crucial role in lymphocyte homing to the gut. The ITGAE/ITGB7 heterodimer forms the αEβ7 integrin receptor, also known as HML-1, which is involved in epithelial cell adhesion. ITGB7 is a highly flexible protein, with a headpiece, lower legs, a transmembrane domain, and a cytoplasmic tail. The I-like domain in the headpiece, in combination with the α subunit, binds ligands. ITGB7 is involved in various cellular processes, including cell migration, adhesion, and signaling.

ITGB7, also known as integrin beta-7, is a protein that plays a crucial role in lymphocyte migration and homing to the gut-associated lymphoid tissue (GALT). ITGB7 forms heterodimers with integrin alpha subunits, specifically ITGA4 (alpha-4) and ITGAE (alpha-E), creating distinct receptors with different functions. The ITGA4/ITGB7 heterodimer, also known as LPAM-1, interacts with MADCAM1, a cell surface adhesion molecule expressed on the vascular endothelium of the gastrointestinal tract. This interaction is essential for lymphocyte homing to the gut. ITGA4/ITGB7 also interacts with VCAM1 and fibronectin, components of the extracellular matrix. The interaction with fibronectin involves specific domains within the CS-1 region of fibronectin. The ITGAE/ITGB7 heterodimer, also known as HML-1, acts as a receptor for E-cadherin. ITGB7 is involved in microbial infections, particularly with HIV-1. ITGB7 interacts with HIV-1 gp120, potentially facilitating viral entry into GALT.

ITGB7 is also known as -.

Associated Diseases

WES Whole Exome Sequencing