ITGA5
Description
The ITGA5 (integrin subunit alpha 5) is a protein-coding gene located on chromosome 12.
Integrin alpha-5 is a protein encoded by the ITGA5 gene in humans. It belongs to the integrin alpha chain family, which are heterodimeric integral membrane proteins consisting of an alpha and a beta chain. ITGA5 encodes the integrin alpha 5 chain. This chain undergoes post-translational cleavage in the extracellular domain, resulting in disulfide-linked light and heavy chains that combine with beta 1 to form a fibronectin receptor. Besides adhesion, integrins are involved in cell-surface mediated signaling. ITGA5 has been shown to interact with GIPC1.
The ITGA5 gene encodes the alpha-5 subunit of the integrin alpha-5/beta-1 (ITGA5:ITGB1) heterodimer, which acts as a receptor for fibronectin and fibrinogen. This receptor recognizes the R-G-D sequence in its ligands and binds to PLA2G2A via a distinct site (site 2), inducing conformational changes and enhancing ligand binding to the classical ligand-binding site (site 1). ITGA5:ITGB1 also functions as a receptor for fibrillin-1 (FBN1), mediating R-G-D-dependent cell adhesion to FBN1. Furthermore, ITGA5:ITGB1 acts as a receptor for fibronectin (FN1) and IL1B, mediating R-G-D-dependent cell adhesion to FN1 and playing a crucial role in IL1B signaling. ITGA5:ITGB3 serves as a receptor for soluble CD40LG, essential for CD40/CD40LG signaling.
ITGA5 is also known as CD49e, FNRA, VLA-5, VLA5A.
