IST1
Description
The IST1 (IST1 factor associated with ESCRT-III) is a protein-coding gene located on chromosome 16.
IST1 is an ESCRT-III-like protein that plays a crucial role in cytokinesis, nuclear envelope reassembly, and endosomal tubulation. It is essential for efficient abscission during cytokinesis by recruiting VPS4A and/or VPS4B to the midbody of dividing cells. During late anaphase, IST1 participates in nuclear envelope reassembly and mitotic spindle disassembly alongside the ESCRT-III complex. It facilitates the recruitment of SPAST to the nuclear membrane, leading to microtubule severing. IST1 is recruited to the reforming nuclear envelope during anaphase by LEMD2 and regulates early endosomal tubulation by mediating the recruitment of SPAST.
IST1 is also known as CHMP8, OLC1.
