IRF8

Description

The IRF8 gene encodes interferon regulatory factor 8, a transcription factor that plays a crucial role in the development and function of immune cells, particularly myeloid cells. IRF8 is involved in regulating the expression of genes involved in immune responses, inflammation, and cell differentiation. It is highly expressed in immune cells like macrophages, dendritic cells, and neutrophils, and its activity is tightly controlled by various signaling pathways.

Associated Diseases

• Myeloid malignancies (acute myeloid leukemia, myelodysplastic syndromes)
• Immune deficiency disorders (common variable immunodeficiency)
• Autoimmune diseases (rheumatoid arthritis, systemic lupus erythematosus)
• Inflammatory bowel disease

Did you know?

Mutations in the IRF8 gene can lead to a variety of immune disorders, highlighting its essential role in maintaining immune homeostasis.