IPMK

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Description

The IPMK (inositol polyphosphate multikinase) is a protein-coding gene located on chromosome 10.

Inositol-polyphosphate multikinase (EC 2.7.1.151, IpK2, IP3/IP4 6-/3-kinase, IP3/IP4 dual-specificity 6-/3-kinase, IpmK, ArgRIII, AtIpk2alpha, AtIpk2beta, inositol polyphosphate 6-/3-/5-kinase) is an enzyme with systematic name ATP:1D-myo-inositol-1,4,5-trisphosphate 6-phosphotransferase. This enzyme catalyses the following chemical reaction:

2 ATP + 1D-myo-inositol 1,4,5-trisphosphate ⇌ 2 ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate (overall reaction) (1a) ATP + 1D-myo-inositol 1,4,5-trisphosphate ⇌ ADP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate (1b) ATP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate ⇌ ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate

This enzyme also phosphorylates Ins(1,4,5)P3 to Ins(1,3,4,5)P4, Ins(1,3,4,5)P4 to Ins(1,3,4,5,6)P5, and Ins(1,3,4,5,6)P4 to Ins(PP)P4, isomer unknown.

Inositol phosphate kinase with a broad substrate specificity. Phosphorylates inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) first to inositol 1,3,4,5-tetrakisphosphate and then to inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5). Phosphorylates inositol 1,3,4,6-tetrakisphosphate (Ins(1,3,4,6)P4). Phosphorylates inositol 1,4,5,6-tetrakisphosphate (Ins(1,4,5,6)P4). Phosphorylates glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate to glycero-3-phospho-1D-myo-inositol 3,4,5-trisphosphate. Plays an important role in MLKL-mediated necroptosis via its role in the biosynthesis of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). Binding of these highly phosphorylated inositol phosphates to MLKL mediates the release of an N-terminal auto-inhibitory region, leading to activation of the kinase. Essential for activated phospho-MLKL to oligomerize and localize to the cell membrane during necroptosis. Required for normal embryonic development, probably via its role in the biosynthesis of inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) and inositol hexakisphosphate (InsP6).

IPMK is also known as -.

Associated Diseases

• hereditary neuroendocrine tumor of small intestine
• breast cancer
• spina bifida-hypospadias syndrome
• isolated spina bifida
• anencephaly 1
• muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type a, 10