INPP5F
Description
The INPP5F (inositol polyphosphate-5-phosphatase F) is a protein-coding gene located on chromosome 10.
INPP5F is a gene that codes for a protein called Inositol polyphosphate-5-phosphatase F. This protein breaks down certain molecules called inositol phosphates, specifically phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. It has a specific domain called 'Sac domain' and has different forms due to alternative splicing. This gene is important for various cellular processes and plays a role in cell signaling and regulation.
INPP5F primarily acts on phosphatidylinositol 4-phosphate, a key lipid in cell signaling. It might collaborate with OCRL to sequentially remove phosphate groups from phosphatidylinositol 4,5-bisphosphate, contributing to endocytic recycling, the process of bringing back essential molecules to the cell surface. This enzyme is also involved in the recycling of transferrin receptor and integrins, which are crucial for cell migration. INPP5F regulates the AKT/GSK3B signaling pathway by reducing phosphorylation of AKT and GSK3B, two important proteins involved in cell growth and survival. It negatively regulates STAT3 signaling, a pathway involved in cell growth and inflammation, by inhibiting STAT3 phosphorylation and movement into the cell nucleus. Additionally, INPP5F plays a role in regulating the size of heart muscle cells and their response to stress. It may also act as a negative regulator of nerve cell regeneration after injury to the central nervous system.
INPP5F is also known as MSTP007, MSTPO47, SAC2, hSAC2.
