INHBB
Inhibin Beta B (INHBB): A Key Hormone in Female Fertility
Description
Inhibin beta B (INHBB) is a hormone primarily produced by the ovaries in females. It belongs to the inhibin family of hormones that play a crucial role in regulating the reproductive cycle. INHBB is specifically involved in the suppression of follicle-stimulating hormone (FSH) secretion from the pituitary gland.
Mechanism of Action
INHBB acts as a negative feedback regulator of FSH production. When levels of INHBB are high, it suppresses FSH secretion. This in turn prevents the growth and development of ovarian follicles, which are necessary for egg maturation and ovulation.
Associated Diseases
1. Polycystic Ovary Syndrome (PCOS): PCOS is a hormonal disorder characterized by irregular menstrual cycles and multiple small cysts on the ovaries. High levels of INHBB in PCOS patients have been linked to the suppression of FSH and the subsequent inhibition of follicle development.
2. Female Infertility: INHB mutations or deficiencies can lead to infertility in women. Abnormal INHBB levels disrupt the delicate balance of reproductive hormones, hindering follicle growth and ovulation.
3. Granulosa Cell Tumors: Granulosa cell tumors are rare ovarian tumors that often produce high levels of INHBB. This excessive production can suppress FSH secretion and disrupt normal ovarian function.
Did you Know ?
Studies have shown that approximately 10% of women with infertility have INHBB gene mutations or deficiencies.
