INHBA
Description
The INHBA (inhibin subunit beta A) is a protein-coding gene located on chromosome 7.
Inhibin, beta A, also known as INHBA, is a protein encoded by the INHBA gene. It is a subunit of both activin and inhibin, which are closely related glycoproteins with opposing biological effects. The inhibin beta A subunit joins with the alpha subunit to form inhibin, which inhibits FSH secretion. Inhibin has been shown to negatively regulate gonadal stromal cell proliferation and to have tumor-suppressor activity. Serum levels of inhibin can be used as a marker for granulosa-cell tumors. The beta A subunit also forms a homodimer, activin A, and a heterodimer, activin AB, both of which stimulate FSH secretion. The beta A subunit mRNA is identical to the erythroid differentiation factor subunit mRNA, suggesting that only one gene encodes for this mRNA in the human genome.
INHBA is also known as EDF, FRP.
