ING3
Description
The ING3 (inhibitor of growth family member 3) is a protein-coding gene located on chromosome 7.
ING3 is a gene that encodes a protein similar to ING1, a tumor suppressor. ING3 contains a PHD finger, a common motif involved in chromatin remodeling. It can activate p53-regulated promoters, including those of p21/waf1 and bax, leading to growth inhibition and apoptosis. Loss or reduced expression of ING3 has been linked to head and neck cancers. Two different protein isoforms are produced due to alternative splicing.
ING3 is a component of the NuA4 histone acetyltransferase (HAT) complex, which plays a role in activating gene transcription. NuA4 acetylates histones H4 and H2A, influencing the interaction between nucleosomes and DNA, and promoting the binding of other transcription-regulating proteins. This complex is crucial for processes including growth induction, tumor suppressor-mediated growth arrest and senescence, apoptosis, and DNA repair. NuA4 can also directly participate in DNA repair by being recruited to damaged DNA sites. ING3 is also part of a SWR1-like complex that removes histone H2A.Z/H2AZ1 from nucleosomes.
ING3 is also known as Eaf4, ING2, MEAF4, p47ING3.
Associated Diseases
- multiple sclerosis
- Alzheimer disease
- lysosomal storage disease
- Parkinson disease
- pachyonychia congenita
- Mobius syndrome
- cancer
