ING2

---

Description

The ING2 (inhibitor of growth family member 2) is a protein-coding gene located on chromosome 4.

ING2, or Inhibitor of growth protein 2, is a human protein encoded by the ING2 gene. It belongs to the ING family, which is involved in regulating the activity of enzymes that add or remove acetyl groups from histones (HATs and HDACs). ING family members participate in DNA repair and programmed cell death (apoptosis).

ING2 appears to be involved in the activation of the p53 tumor suppressor gene and in p53-dependent cell death pathways. It likely does this by promoting the acetylation of p53. ING2 is also part of a complex called the mSin3A corepressor complex, which is involved in removing acetyl groups from histones in the DNA. ING2's activity is regulated by its binding to certain lipids called phosphoinositides.

ING2 is also known as ING1L, p33ING2.

Associated Diseases

• ovarian cancer
• endometrial cancer
• male infertility with teratozoospermia due to single gene mutation
• partial chromosome Y deletion
• spinocerebellar ataxia type 32
• dehydrated hereditary stomatocytosis
• isochromosomy Yp
• spermatogenic failure 65
• spermatogenic failure 63
• congenital bilateral absence of vas deferens
• partial androgen insensitivity syndrome
• spermatogenic failure 25
• spermatogenic failure 51
• spermatogenic failure 39
• spermatogenic failure 44
• spermatogenic failure, X-linked, 3