IMPA2

Description

The IMPA2 (inositol monophosphatase 2) is a protein-coding gene located on chromosome 18.

IMPA2 is a 32 kDa enzyme encoded by the IMPA2 gene in humans. It dephosphorylates myo-inositol monophosphate to myo-inositol. IMPA2's function appears similar to IMPA1 within tissues, but the genes are expressed differently, with IMPA2 highly expressed in certain brain tissues and the kidney lumen. IMPA2 exists as a homodimer within cells and cannot form heterodimers with IMPA1.

IMPA2 utilizes a range of substrates including myo-inositol monophosphates, scylloinositol 1,4-diphosphate, glucose-1-phosphate, beta-glycerophosphate, and 2'-AMP. Research suggests it may be the target of lithium Li(+) action in the brain.

IMPA2 is also known as -.

Associated Diseases

• endometrial cancer
• nonpapillary renal cell carcinoma
• congenital hydronephrosis
• congenital primary megaureter
• bipolar disorder
• Ochoa syndrome
• renal hypoplasia
• renal dysplasia
• schizophrenia