IMP3
Description
The IMP3 (IMP U3 small nucleolar ribonucleoprotein 3) is a protein-coding gene located on chromosome 15.
IMP3 is a protein encoded by the IMP3 gene in humans. It is the human homolog of the yeast Imp3 protein. IMP3 localizes to the nucleoli and interacts with the U3 snoRNP complex. It contains an S4 domain.
IMP3 is a crucial component of the U3 small nucleolar ribonucleoprotein (U3 snoRNP), a complex essential for the initial steps of pre-18S ribosomal RNA processing. As part of the SSU processome, the first precursor of the small eukaryotic ribosomal subunit, IMP3 plays a vital role in the assembly of the ribosome. During this process, IMP3, along with other factors, guides the folding, modification, rearrangement, and cleavage of pre-ribosomal RNA, ultimately leading to the production of functional ribosomal subunits. Additionally, IMP3 contributes to the targeted degradation of pre-ribosomal RNA by the RNA exosome.
IMP3 is also known as BRMS2, C15orf12, MRPS4.
Associated Diseases
- Parkinson disease
- lysosomal storage disease
- Alzheimer disease
- multiple sclerosis
- type 2 diabetes mellitus
- cancer
