IMMT
Description
The IMMT (inner membrane mitochondrial protein) is a protein-coding gene located on chromosome 2.
IMMT encodes a protein located in the inner mitochondrial membrane (IMM) that is crucial for the structure and function of mitochondria. It is a core subunit of the MICOS complex, which is directly associated with cristae junctions (CJ). IMMT exists in two isoforms of different sizes, with its N-terminus anchored to the IMM and the majority of the protein extending into the inner mitochondrial space (IMS). IMMT is an evolutionary ancient protein, with homologs found in anaerobic prokaryotes. It plays a crucial role in maintaining the stability of the MICOS complex and shaping the morphology of the mitochondrial cristae. IMMT interacts with numerous other proteins, including other MICOS complex components, SAM complex components, and proteins involved in mitochondrial intermembrane space bridging.
IMMT is a subunit of the MICOS complex, a large protein complex within the mitochondrial inner membrane. The MICOS complex plays essential roles in maintaining the structure of cristae junctions, the overall architecture of the inner membrane, and establishing contact points between the inner and outer membranes. IMMT is crucial for preserving the integrity and stability of the MICOS complex and shaping the morphology of the mitochondrial cristae.
IMMT is also known as HMP, MICOS60, MINOS2, Mic60, P87, P87/89, P89, PIG4, PIG52.
