IL9
Description
The IL9 (interleukin 9) is a protein-coding gene located on chromosome 5.
IL-9 can refer to: Interleukin-9, a cytokine involved in immune responses.
IL-9 is a multifunctional cytokine primarily produced by T helper 2 lymphocytes, as well as mast cells and NKT cells. It plays a crucial role in the immune response to parasites, influencing intestinal epithelial permeability and adaptive immunity. IL-9 also drives the differentiation of specific T-cell subsets, including IL-17 producing helper T-cells (TH17), and promotes mast cell proliferation and differentiation. Its signaling pathway involves a receptor composed of IL9R and IL2RG subunits. Upon receptor activation, JAK1 and JAK3 kinases are rapidly activated, leading to STAT1, STAT3, and STAT5-mediated transcriptional programs. STAT1 appears to solely mediate the induction of differentiation genes, while STAT3 and STAT5 are responsible for protecting cells from apoptosis.
IL9 is also known as HP40, IL-9, P40.
