IL5RA
Description
The IL5RA (interleukin 5 receptor subunit alpha) is a protein-coding gene located on chromosome 3.
IL5RA, also known as CD125 (Cluster of Differentiation 125), is a subunit of the Interleukin-5 receptor. IL5RA also denotes its human gene. The protein encoded by this gene is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. The receptor is composed of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL5 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL5. This protein has been found to interact with syndecan binding protein (syntenin), which is required for IL5 mediated activation of the transcription factor SOX4. Six alternatively spliced transcript variants encoding three distinct isoforms have been reported. IL5RA has been shown to interact with Interleukin 5, Janus kinase 2, Protein unc-119 homolog, and SDCBP.
IL5RA is a cell surface receptor crucial for eosinophil survival, differentiation, and chemotaxis. It forms a heterodimeric receptor with CSF2RB subunit, binding to interleukin-5. In resting conditions, IL5RA interacts with JAK2. Upon receptor activation, JAK2 is stimulated, triggering the JAK-STAT pathway.
IL5RA is also known as CD125, CDw125, HSIL5R3, IL5R.
