IL36A
Description
The IL36A (interleukin 36 alpha) is a protein-coding gene located on chromosome 2.
Interleukin-36 alpha, also known as interleukin-1 family member 6 (IL1F6), is a protein that in humans is encoded by the IL36A gene.
IL36A, also known as IL1F6, is a cytokine that binds to the IL1RL2/IL-36R receptor, triggering the activation of NF-κB and MAPK signaling pathways in target cells. This activation is linked to a pro-inflammatory response. IL36A is part of the IL-36 signaling system, which is believed to be present in epithelial barriers and involved in local inflammatory responses. It shares similarities with the IL-1 system, as they both use the IL1RAP coreceptor. IL36A has a role in skin inflammation by acting on keratinocytes, dendritic cells, and indirectly on T-cells, leading to tissue infiltration, cell maturation, and proliferation. In cultured keratinocytes, IL36A induces the expression of chemokines like CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CXCL8, CCL20, and CXCL1, as well as pro-inflammatory cytokines such as TNF-α, IL-8, and IL-6. In cultured monocytes, IL36A upregulates the expression of IL-1A, IL-1B, and IL-6. It is also involved in myeloid dendritic cell maturation by upregulating CD83, CD86, and HLA-DR surface expression. In monocyte-derived dendritic cells, it promotes dendritic cell maturation and drives T-cell proliferation. IL36A may also play a role in pro-inflammatory effects in the lung.
IL36A is also known as FIL1, FIL1(EPSILON), FIL1E, IL-1F6, IL1(EPSILON), IL1F6.
