IL31RA : interleukin 31 receptor A
Description
The IL31RA (interleukin 31 receptor A) is a protein-coding gene located on chromosome 5.
The IL31RA gene provides instructions for making a protein called interleukin-31 receptor alpha subunit (IL-31RA). This protein is one piece (subunit) of the IL-31 receptor, which is embedded in the cell membrane of many types of cells throughout the body. At the cell surface, the IL-31 receptor interacts with a protein called interleukin 31 (IL-31). The receptor and IL-31 fit together like a lock and its key, triggering a series of chemical signals inside the cell. These signals stimulate itching (pruritus) and an immune system response called inflammation, although the mechanism is not completely understood.
IL31RA forms a receptor complex with OSMR, activating STAT3, STAT1, and STAT5. It contributes to skin immunity. IL31RA mediates itch, likely through TRPA1 and TRPV1 ion channels. It regulates myeloid progenitor cell numbers and cycling in bone marrow and promotes their survival.
IL31RA is also known as CRL, CRL3, GLM-R, GLMR, GPL, IL-31RA, PLCA2, PRO21384, hGLM-R, zcytoR17.
