IL3
Description
The IL3 (interleukin 3) is a protein-coding gene located on chromosome 5.
IL-3 may refer to:
IL-3 is a cytokine primarily secreted by activated T-lymphocytes, mast cells, and osteoblastic cells. It regulates the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. IL-3 also stimulates mature basophils, eosinophils, and monocytes to become functionally activated. Additionally, it plays a vital role in neural cell proliferation and survival. Furthermore, IL-3 participates in bone homeostasis by inhibiting osteoclast differentiation through the prevention of NF-kappa-B nuclear translocation and activation. Mechanistically, IL-3 exerts its effects through a receptor composed of IL3RA and IL3RB subunits. Receptor stimulation activates JAK2 kinase, leading to STAT5-mediated transcriptional programs. In non-hematopoietic systems, IL-3 promotes cell survival under oxidative stress by activating pathways involving PI3K/AKT and ERK.
IL3 is also known as IL-3, MCGF, MULTI-CSF.
