IL2RA

Description

The IL2RA gene, located on chromosome 10, encodes the alpha chain of the interleukin-2 receptor (IL-2R), a crucial component of the immune system. IL-2R plays a pivotal role in regulating the growth, differentiation, and survival of T cells, a type of white blood cell essential for adaptive immunity. Upon binding to its ligand, IL-2, IL-2R triggers intracellular signaling pathways that activate T cells, enabling them to effectively respond to infections and other immune challenges.

Associated Diseases

• Common Variable Immunodeficiency (CVID)
• Autoimmune diseases (e.g., rheumatoid arthritis, systemic lupus erythematosus)
• Cancer (e.g., lymphoma, leukemia)

Did you know?

Mutations in the IL2RA gene can lead to both immunodeficiency and autoimmunity, highlighting the delicate balance it maintains in the immune system.