IL23R

Description

The IL23R gene encodes the interleukin-23 receptor, a crucial protein involved in the immune system‘s response to infections and inflammation. This receptor binds to interleukin-23 (IL-23), a cytokine that plays a key role in activating specific immune cells, such as T helper 17 (Th17) cells, which are important in combating infections. Variations in the IL23R gene have been linked to various autoimmune and inflammatory diseases, highlighting its significance in immune regulation and disease susceptibility.

Associated Diseases

• Crohn‘s disease
• Psoriasis
• Ankylosing spondylitis
• Ulcerative colitis
• Inflammatory bowel disease (IBD)
• Multiple sclerosis
• Psoriatic arthritis
• Juvenile idiopathic arthritis
• Hidradenitis suppurativa

Did you know?

The IL23R gene is located on chromosome 1p31.3, a region of the genome known to harbor genes involved in immune regulation and inflammation.