IL22RA1

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Description

The IL22RA1 (interleukin 22 receptor subunit alpha 1) is a protein-coding gene located on chromosome 1.

IL22RA1 (Interleukin 22 receptor, alpha 1) is a protein encoded by the IL22RA1 gene in humans. It belongs to the class II cytokine receptor family and acts as a receptor for interleukin 22 (IL22). The IL22 receptor is a complex composed of IL22RA1 and interleukin 10 receptor, beta (IL10RB/CRFB4), a subunit shared with the interleukin 10 (IL10) receptor complex. The IL22RA1 gene and interleukin 28 receptor, alpha (IL28RA) are located together in a cytokine receptor gene cluster on chromosome 1p36.

IL22RA1 forms a receptor complex with IL10RB, enabling signaling by IL22 through the JAK/STAT pathway. IL22 activation also triggers the MAPK1/MAPK3 and Akt kinases pathways. IL22RA1, in combination with IL20RB, forms a receptor for IL20 and IL24, also signaling via STAT activation. IL24, through IL22RA1, mediates antiangiogenic activity and inhibits endothelial cell tube formation and differentiation.

IL22RA1 is also known as CRF2-9, IL22R, IL22R1.

Associated Diseases

• COVID-19
• cancer
• plasma fibronectin deficiency
• Crigler-Najjar syndrome type 2
• Miyoshi myopathy
• transient familial neonatal hyperbilirubinemia
• congenital enteropathy due to enteropeptidase deficiency
• congenital lethal erythroderma
• gluthathione peroxidase deficiency
• graft versus host disease
• Rotor syndrome
• Dubin-Johnson syndrome
• hypercholanemia, familial, 2
• hemolytic anemia due to glutathione reductase deficiency
• Crigler-Najjar syndrome type 1
• neonatal intrahepatic cholestasis due to citrin deficiency