IL20RA

Description

The IL20RA (interleukin 20 receptor subunit alpha) is a protein-coding gene located on chromosome 6.

The Interleukin 20 receptor, alpha subunit (IL20RA) is a component of the interleukin-20 receptor, interleukin-26 receptor, and interleukin-24 receptor. IL20RA is also known as IL20R1. IL20RA plays a role in both pro-inflammatory and anti-inflammatory responses, signaling through the JAK-STAT pathway. It is found in various tissues like skin, lungs, ovaries, testes, and placenta, with lower expression in the intestine and liver. It is also present in some immune cells. IL20RA, along with the IL-20 receptor, beta subunit (IL20RB), forms the heterodimeric interleukin-20 receptor, which binds the cytokines IL-19, IL-20, and IL-24. IL20RA also forms a complex with the IL-10 receptor, beta subunit (IL10RB), which binds the cytokine IL-26. Receptors composed of IL20RA signal through the JAK-STAT pathway. This pathway involves the activation of JAKs, linked to the intracellular domains of IL20R, upon cytokine binding to IL20RA and the beta subunit. JAKs phosphorylate tyrosine residues in the longer alpha chains of IL20RA. STAT then binds to the docking sites created by JAK phosphorylation and gets phosphorylated by JAK. Phosphorylated STATs dimerize and translocate to the nucleus to act as transcription factors.

IL20RA is also known as CRF2-8, IL-20R-alpha, IL-20R1, IL-20RA.

Associated Diseases

• type 2 diabetes mellitus
• multiple sclerosis
• hemoglobin E-beta-thalassemia syndrome
• melorheostosis
• IRIDA syndrome
• isolated asymptomatic elevation of creatine phosphokinase
• dacryocystitis-osteopoikilosis syndrome
• osteosclerosis-ichthyosis-premature ovarian failure syndrome
• Kallmann syndrome
• acute kidney failure
• Mazabraud syndrome
• 12q14 microdeletion syndrome
• osteomesopyknosis
• pyknoachondrogenesis
• Rh deficiency syndrome
• hyperostosis corticalis generalisata
• pentosuria
• gluthathione peroxidase deficiency