IL20
Description
The IL20 (interleukin 20) is a protein-coding gene located on chromosome 1.
IL-20 or IL 20 may refer to:
IL-20 is a pro-inflammatory and angiogenic cytokine primarily secreted by monocytes and skin keratinocytes. It plays a vital role in immune responses, regulating inflammatory responses, hemopoiesis, and epidermal cell differentiation. IL-20 enhances tissue remodeling and wound-healing activities, restoring epithelial homeostasis during infections and inflammatory responses to maintain tissue integrity. It affects various actin-mediated functions in activated neutrophils, leading to the inhibition of phagocytosis, granule exocytosis, and migration. IL-20 exerts its effects through the type I IL-20 receptor complex, composed of IL20RA and IL20RB, or through a second receptor complex called the type II IL-20 receptor complex, consisting of IL22RA1 and IL20RB. It acts as an arteriogenic and vascular remodeling factor by activating signaling processes, including phosphorylations of JAK2 and STAT5, as well as activation of the serine and threonine kinases AKT and ERK1/2. Alternatively, IL-20 can activate STAT3 phosphorylation and transcriptional activity in a JAK2, ERK1/2, and p38 MAPK-dependent manner in keratinocytes. It forms a 1:1:1 heterotrimeric complex with its primary high-affinity heterodimeric receptor IL20RA/IL20RB.
IL20 is also known as IL-20, IL10D, ZCYTO10.
Associated Diseases
- microphthalmia with limb anomalies
- Ehlers-Danlos syndrome, dermatosparaxis type
- isolated asymptomatic elevation of creatine phosphokinase
- urinary bladder carcinoma
- pentosuria
