IL1R2
Description
The IL1R2 (interleukin 1 receptor type 2) is a protein-coding gene located on chromosome 2.
The IL1R2 gene encodes a decoy receptor for certain cytokines belonging to the interleukin-1 receptor family. This receptor binds IL1A, IL1B, and IL1Ra, preventing them from activating their signaling receptors and thus inhibiting their signaling. IL1R2 also interacts with IL-1RAcP, a component of the IL-1 signaling complex, forming a non-signaling complex. IL4 is reported to antagonize interleukin 1 activity by inducing the expression and release of IL1R2. The gene, along with three others, forms a cytokine receptor gene cluster on chromosome 2q12. Two alternatively spliced transcript variants have been reported, both encoding the same protein.
IL1R2 acts as a decoy receptor for interleukin-1 alpha (IL1A), interleukin-1 beta (IL1B), and interleukin 1 receptor antagonist (IL1Ra). It binds to these cytokines, preventing them from activating their signaling receptors, thereby reducing IL1B activity. IL1R2 can also bind to IL1RAP, a component of the IL-1 signaling complex, forming a non-signaling complex that further modulates cellular responses. Both membrane-bound and secreted forms of IL1R2 exist, with the secreted form preferentially binding IL1B and forming complexes with secreted IL1RAP, potentially playing a major role in IL1B neutralization.
IL1R2 is also known as CD121b, CDw121b, IL-1R-2, IL-1RT-2, IL-1RT2, IL1R2c, IL1RB.
