IL18R1
Description
The IL18R1 (interleukin 18 receptor 1) is a protein-coding gene located on chromosome 2.
The interleukin-18 receptor 1 (IL18R1) is a protein that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. This receptor is also known as CDw218a. The expression of this receptor is induced by IFN-alpha and IL12 in NK and T cells. IL18R1 is located on chromosome 2q, along with other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2).
The IL18R1 protein forms a complex with IL18RAP and IL18, acting as the ligand-binding component in this complex. This interaction triggers downstream signaling pathways, leading to NF-kappa-B and JNK activation, which are involved in the production of pro-inflammatory cytokines. IL18R1 also interacts with SLC12A3, and this interaction is enhanced by IL18 treatment. IL18R1 plays a critical role in the synthesis of interferon-gamma (IFNG) from T helper 1 (Th1) cells, a crucial cytokine in immune responses. IL18R1 is responsible for binding the pro-inflammatory cytokine IL18 but does not bind IL1A or IL1B. The IL18R1 protein functions independently of SLC12A3 or in a complex with SLC12A3, contributing to the production of cytokines induced by IL18.
IL18R1 is also known as CD218a, CDw218a, IL-18R-alpha, IL-18Ralpha, IL-1Rrp, IL18RA, IL18Ralpha2, IL1RRP.
