IL17RD
Description
The IL17RD (interleukin 17 receptor D) is a protein-coding gene located on chromosome 3.
Interleukin 17 receptor D (IL-17RD), also known as Sef, is a protein encoded by the IL17RD gene in humans. It is a membrane protein belonging to the interleukin-17 receptor (IL-17R) family, with multiple isoforms generated through alternative splicing. IL-17RD has been shown to limit fibroblast growth factor receptor (FGFR) signaling and is part of the IL-17 receptor signaling complex. It was initially discovered during a large-scale in situ hybridization screen for genes regulating zebrafish embryogenesis. IL-17RD co-immunoprecipitates with FGF receptor (FGFR) and inhibits FGF signaling by interfering with signal transduction, not by affecting ligand binding to FGFR. IL-17RD is a type I transmembrane protein with an extracellular Ig-like domain followed by a fibronectin type III domain, a transmembrane domain, and an intracellular SEFIR domain. The SEFIR domain contains regions similar to the TIR domain, found in Toll-like receptors (TLRs), interleukin 1 family receptors, and adaptor proteins involved in their signaling pathways.
IL17RD acts as a feedback inhibitor of fibroblast growth factor (FGF)-mediated Ras-MAPK signaling and ERK activation, preventing nuclear translocation of activated ERK without affecting its cytoplasmic phosphorylation. It also mediates JNK activation and may play a role in apoptosis. Additionally, it might inhibit FGF-induced FGFR1 tyrosine phosphorylation and be involved in the early stages of fate specification of GnRH-secreting neurons. IL17RD has been shown to inhibit TGFβ-induced epithelial-to-mesenchymal transition in lens epithelial cells. It interacts with MAP3K7, self-associates, and interacts with FGFR1, FGFR2, and phosphorylated MAP2K1 or MAP2K2. It also associates with a MAP2K1/2-MAPK1/3 complex.
IL17RD is also known as HH18, IL-17RD, IL17RLM, SEF.
