IL17C
Description
The IL17C (interleukin 17C) is a protein-coding gene located on chromosome 16.
IL-17C plays a key role in the innate immune response of epithelial tissues, particularly against intestinal bacteria. It acts in an autocrine manner, stimulating the production of antibacterial peptides and pro-inflammatory molecules to defend against pathogens. IL-17C signals through the NF-κB and MAPK pathways. It works synergistically with other cytokines like IL22, TNF, and IL1β to induce the expression of various antimicrobial peptides, including S100A8, S100A9, REG3A, REG3G, and DEFB2. The role of IL-17C can be both protective and pathogenic depending on the type of inflammation. It can maintain epithelial homeostasis after an inflammatory challenge or contribute to an inflammatory phenotype. Increased IL-17C/IL17RE signaling can also lead to an increased risk of autoimmune diseases.
IL17C is also known as CX2, IL-17C.
Associated Diseases
- major depressive disorder
- acne inversa, familial, 3
- X-linked intellectual disability-seizures-psoriasis syndrome
- hereditary palmoplantar keratoderma, Gamborg-Nielsen type
- acute kidney failure
- ichthyosis, lamellar, autosomal dominant
- common variable immunodeficiency
- immunodeficiency 51
- psoriasis 2
- inborn error of immunity
- intellectual disability, FRA12A type
