IL15RA

Description

The IL15RA (interleukin 15 receptor subunit alpha) is a protein-coding gene located on chromosome 10.

The interleukin-15 receptor, alpha subunit (IL15RA) is a subunit of the interleukin 15 receptor. It is encoded by the IL15RA gene and binds IL15 with very high affinity, independently of other subunits. The IL-15 receptor is composed of three subunits: IL-15R alpha, CD122, and CD132. Two of these subunits, CD122 and CD132, are shared with the receptor for IL-2, but IL-2 receptor has an additional subunit (CD25). The shared subunits contain the cytoplasmic motifs required for signal transduction, and this forms the basis of many overlapping biological activities of IL15 and IL2. However, in vivo the two cytokines have separate biological effects, potentially due to effects of the respective alpha chains, the kinetics and affinity of cytokine-cytokine receptor binding, or due to the availability and concentration of each cytokine. IL-15Ralpha is suggested to allow IL-15 to be produced by one cell, endocytosed by another cell, and then presented to a third party cell. Multiple alternatively spliced transcript variants of this gene have been reported, but the full length sequences of only two variants encoding distinct isoforms are available.

IL15RA is a high-affinity receptor for interleukin-15 (IL-15). It can signal both in cis and trans, where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. In neutrophils, IL15RA binds and activates kinase SYK in response to IL15 stimulation, which is required for IL15-induced phagocytosis. Different isoforms of IL15RA may alter or interfere with signal transduction.

IL15RA is also known as CD215.

Associated Diseases

WES Whole Exome Sequencing