IL15
Description
The IL15 (interleukin 15) is a protein-coding gene located on chromosome 4.
IL-15 can refer to: Interleukin-15 (IL-15), a cytokine that plays a vital role in the development of immune responses.
IL15 is a cytokine that plays a key role in inflammatory and protective immune responses to microbial invaders and parasites. It modulates immune cells of both the innate and adaptive immune systems, stimulating the proliferation of natural killer cells, T-cells and B-cells, and promoting the secretion of various cytokines. In monocytes, IL15 induces the production of IL8 and monocyte chemotactic protein 1/CCL2, chemokines that attract neutrophils and monocytes to infection sites. Unlike most cytokines, IL15 is not secreted in soluble form. It is expressed in association with its high affinity IL15RA on the surface of IL15-producing cells, delivering signals to target cells that express IL2RB and IL2RG receptor subunits. Binding to its receptor triggers the phosphorylation of JAK1 and JAK3, and the recruitment and subsequent phosphorylation of signal transducer and activator of transcription-3/STAT3 and STAT5. In mast cells, IL15 induces rapid tyrosine phosphorylation of STAT6, controlling mast cell survival and release of cytokines like IL4.
IL15 is also known as IL-15.
