IL12RB2
Description
The IL12RB2 (interleukin 12 receptor subunit beta 2) is a protein-coding gene located on chromosome 1.
IL12RB2 is the human gene for the interleukin 12 receptor, beta 2 subunit. This protein is a type I transmembrane protein that forms a complex with IL12Rβ1, creating high-affinity IL12 binding sites and activating IL12-dependent signaling. While IL12Rβ1 is constantly expressed, IL12RB2 expression is increased by interferon gamma. IL12 signaling through the receptor, involving IL12RB2, leads to STAT4 phosphorylation and Th1 cell differentiation. The absence of IL12RB2 results in dysfunctional Th1 differentiation and decreased production of Th1 effector molecules. Increased IL12RB2 expression is associated with inflammatory responses in diseases such as Crohn's disease and leprosy. IL12RB2 interacts with Janus kinase 2.
IL12RB2 acts as a receptor for interleukin-12, triggering signaling through the JAK2/STAT4 pathway. This leads to the proliferation of T cells and NK cells, and promotes T cell differentiation towards the Th1 phenotype by boosting IFN-gamma production.
IL12RB2 is also known as -.
