IKZF4
Description
The IKZF4 (IKAROS family zinc finger 4) is a protein-coding gene located on chromosome 12.
IKZF4 encodes the zinc finger protein Eos, which belongs to the Ikaros family of transcription factors. These factors are expressed in lymphocytes and are involved in controlling lymphoid development.
IKZF4 binds to the Ikaros-binding sequence 5'GGGAATRCC-3' and acts as a transcriptional repressor. It interacts with SPI1 and MITF to suppress transcription of CTSK and ACP5 promoters by recruiting corepressors SIN3A and CTBP2. IKZF4 may be involved in the development of the central and peripheral nervous systems and is essential for the inhibitory function of regulatory T-cells (Treg). It mediates FOXP3-mediated gene silencing in regulatory T-cells (Treg) by recruiting corepressor CTBP1.
IKZF4 is also known as EOS, ZNFN1A4.
