IGSF5
IGF5: The Insulin-Like Growth Factor 5
Description
Insulin-like growth factor 5 (IGF5) is a peptide hormone that belongs to the insulin-like growth factor (IGF) family. It is structurally similar to insulin and plays a crucial role in regulating growth, development, and metabolism. IGF5 is primarily produced by the liver and is found in various tissues throughout the body, including muscle, bone, and cartilage.
Associated Diseases
Dysregulation of IGF5 expression and signaling has been implicated in several diseases, including:
- Beckwith-Wiedemann syndrome: A rare genetic disorder characterized by overgrowth, developmental abnormalities, and an increased risk of childhood cancers.
- Silver-Russell syndrome: A condition causing growth retardation, feeding difficulties, and distinctive facial features.
- Type 2 diabetes: A metabolic disorder characterized by insulin resistance and elevated blood glucose levels.
- Cancer: IGF5 has been linked to the development and progression of certain types of cancer, such as prostate cancer, lung cancer, and breast cancer.
Did you Know ?
Approximately 1 in 10,000 people have Beckwith-Wiedemann syndrome, making it a rare but significant disorder.
