IGF2BP1
Description
The IGF2BP1 (insulin like growth factor 2 mRNA binding protein 1) is a protein-coding gene located on chromosome 17.
Insulin-like growth factor 2 mRNA-binding protein 1 is a protein that in humans is encoded by the IGF2BP1 gene. This gene encodes a member of the IGF-II mRNA-binding protein (IMP) family. The protein encoded by this gene contains four K homology domains and two RNA recognition motifs. It functions by binding to the 5' UTR of the insulin-like growth factor 2 (IGF2) mRNA and regulating IGF2 translation.
IGF2BP1 is an RNA-binding protein that plays a key role in regulating the fate of target mRNAs. It does this by guiding transcripts to cytoplasmic protein-RNA complexes (mRNPs), where they are transported, stored, and shielded from degradation. This process ensures that the mRNAs reach their appropriate locations and are translated at the correct time. IGF2BP1 has a preference for binding to mRNAs containing N6-methyladenosine (m6A), a modification that enhances their stability. It plays a crucial role in axonal regeneration in sensory neurons by controlling the transport and translation of essential transcripts. In addition to its general role in mRNA regulation, IGF2BP1 specifically regulates the translation of ACTB mRNA, which encodes the protein beta-actin. This is crucial for processes such as cell polarity, migration, and neurite outgrowth. It binds to ACTB mRNA in the nucleus and accompanies it to the cytoplasm, preventing translation until the complex reaches its destination near the plasma membrane. IGF2BP1 also regulates the stability and translation of various other mRNAs involved in a range of cellular processes. It stabilizes ABCB1/MDR-1 mRNA, PTGS2 transcripts, and CD44 mRNA, and regulates the localization of IGF2, MYC, TAU, and H19 transcripts. Additionally, it has been implicated in the regulation of cell migration and the control of viral infections, such as those caused by HCV and HIV-1.
IGF2BP1 is also known as CRD-BP, CRDBP, IMP-1, IMP1, VICKZ1, ZBP1.
