IFNL1
Description
The IFNL1 (interferon lambda 1) is a protein-coding gene located on chromosome 19.
IFNL1 is a cytokine with a wide range of biological activities, including antiviral, antitumor, and immunomodulatory effects. It plays a key role in the body's defense against viral infections, particularly in epithelial tissues. IFNL1 binds to a specific receptor complex on epithelial cells, triggering the activation of the JAK/STAT signaling pathway. This activation leads to the production of IFN-stimulated genes (ISGs), which establish an antiviral state within the cell. IFNL1's activity is primarily restricted to epithelial cells due to the specific expression of its receptor, IFNLR1, in these cells. Furthermore, IFNL1 contributes to immune regulation by increasing the expression of MHC class I antigens.
IFNL1 is also known as IL-29, IL29.
Associated Diseases
- thyroid gland adenocarcinoma
- COVID-19
- microphthalmia with limb anomalies
- systemic lupus erythematosus
- immune deficiency, familial variable
- isolated hyperchlorhidrosis
- cryopyrin-associated periodic syndrome
- hearing loss-familial salivary gland insensitivity to aldosterone syndrome
