IFIT2

Description

The IFIT2 (interferon induced protein with tetratricopeptide repeats 2) is a protein-coding gene located on chromosome 10.

IFIT2 (Interferon-induced protein with tetratricopeptide repeats 2) is a human protein encoded by the IFIT2 gene. IFIT2 may play a role in preventing tumor progression. Lower levels of IFIT2 have been found in human papillomavirus-positive neoplastic keratinocytes derived from uterine cervical preneoplastic lesions, suggesting a potential link between IFIT2 and tumorigenesis. It may also be a valuable prognostic marker for the progression of uterine cervical preneoplastic lesions.

IFIT2 is an interferon-induced antiviral protein that blocks the expression of viral messenger RNAs lacking a 2'-O-methylation modification at the 5' cap. This methylation acts as a molecular tag that distinguishes host mRNAs from viral mRNAs. Viruses have evolved mechanisms to circumvent this defense, such as producing their own 2'-O-methyltransferases or stealing capped host mRNA molecules. IFIT2 binds to AU-rich viral RNA sequences, regardless of whether they have a 5' triphosphate, and this binding is essential for its antiviral activity. IFIT2 can also induce apoptosis.

IFIT2 is also known as G10P2, GARG-39, IFI-54, IFI-54K, IFI54, IFIT-2, ISG-54, ISG-54 K, ISG-54K, ISG54, P54, cig42.

Associated Diseases

WES Whole Exome Sequencing