IFI6
Description
The IFI6 (interferon alpha inducible protein 6) is a protein-coding gene located on chromosome 1.
IFI6, the gene encoding Interferon alpha-inducible protein 6, was initially identified as one of the many genes activated by interferon. This protein is believed to play a critical role in regulating apoptosis. The gene includes a mini-satellite region near the end of the second exon, consisting of 26 repeats of a 12-nucleotide sequence resembling the mammalian splice donor consensus sequence. Alternative splicing using these repeats as splice donor sites results in different protein isoforms. IFI6 exhibits antiviral activity against several members of the Flaviviridae family, including DENV, YFV, ZIKV, and WNV. IFI6 inhibits viral replication by preventing the formation of virus-induced membrane structures, which serve as replication organelles.
IFI6 is an interferon-stimulated protein that plays a key role in the innate immune response against various viruses. It inhibits flavivirus replication by blocking the formation of double-membrane vesicles, essential for viral replication, within the endoplasmic reticulum. IFI6 also exhibits antiviral activity against hepatitis C virus (HCV) by suppressing the EGFR signaling pathway, necessary for viral entry into cells. Additionally, within the nucleus, IFI6 restricts hepatitis B virus (HBV) promoter activity, significantly reducing viral replication and gene expression. IFI6 influences apoptosis, acting as a negative regulator of the intrinsic apoptotic pathway and TNFSF10-induced apoptosis. However, IFI6 has also been shown to promote apoptosis under certain conditions. Furthermore, IFI6 modulates the innate immune response mediated by RIGI by preventing its activation.
IFI6 is also known as 6-16, FAM14C, G1P3, IFI-6-16, IFI616.
