IFI30
Description
The IFI30 (IFI30 lysosomal thiol reductase) is a protein-coding gene located on chromosome 19.
IFI30 is a human gene encoding a lysosomal thiol reductase. This enzyme reduces protein disulfide bonds at low pH, promoting protein unfolding. It is constitutively expressed in antigen-presenting cells and induced by gamma-interferon in other cell types. IFI30 plays a crucial role in MHC class II-restricted antigen processing.
IFI30 encodes a lysosomal thiol reductase that reduces protein disulfide bonds, facilitating protein unfolding for lysosomal degradation. It plays a critical role in antigen processing, enabling the generation of MHC class II-restricted epitopes from disulfide-containing antigens through endocytic reduction. Additionally, IFI30 facilitates MHC class I-restricted recognition of exogenous disulfide-containing antigens by CD8+ T-cells, contributing to cross-presentation.
IFI30 is also known as GILT, IFI-30, IP-30, IP30.
