ICAM3
Description
The ICAM3 (intercellular adhesion molecule 3) is a protein-coding gene located on chromosome 19.
ICAM3 (Intercellular adhesion molecule 3), also known as CD50, is a protein encoded by the ICAM3 gene. It is found on the surface of leukocytes, which are white blood cells that play a crucial role in the immune system. ICAM3 allows cells to adhere to each other by binding to specific integrin receptors. This function is vital for immune cell response, enabling communication between T cells and dendritic cells, ultimately leading to T cell activation. ICAM3 also participates in the clearance of apoptotic (dying) cells by attracting macrophages, which engulf and break down dying cells through a process called phagocytosis. ICAM3 is a type I transmembrane glycoprotein with five extracellular immunoglobulin domains. It is a large protein with a molecular weight of 110-160 kDa.
ICAM3 is also known as CD50, CDW50, ICAM-R.
