Hydrochlorothiazide
Hydrochlorothiazide is a commonly prescribed antihypertensive medication, classified as a thiazide diuretic. It’s used to treat high blood pressure and fluid retention by helping the body get rid of excess salt and water. Despite its widespread use, less than 50% of patients achieve optimal blood pressure control with this medication1.
Impact of Genes
Genetic factors can significantly influence a patient’s response to Hydrochlorothiazide. Studies have integrated metabolomic and genomic profiles to identify genetic markers associated with blood pressure response to the drug. Notably, polymorphisms in genes like PRKAG2, DCC, and EPHX2 have been linked to variability in patient responses1.
Ways to Identify Problems
Patients may exhibit a wide range of responses to Hydrochlorothiazide, and identifying issues can be challenging. Monitoring blood pressure levels before and after starting the medication is crucial. Genetic testing may also help predict individual responses and identify any potential problems early on.
Ways to Improve
Personalized medicine approaches, including pharmacogenomics, can improve treatment outcomes. By understanding the genetic basis of hypertension and the patient’s unique genetic makeup, healthcare providers can tailor treatments for better efficacy and fewer side effects2.
Did you know
A genetic response score created from identified genetic markers explained 11.3% and 11.9% of the variability in Hydrochlorothiazide’s systolic and diastolic blood pressure responses, respectively. This highlights the potential of genetic insights in enhancing treatment precision1.
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