HUS1

Description

The HUS1 (HUS1 checkpoint clamp component) is a protein-coding gene located on chromosome 7.

HUS1 is a protein encoded by the HUS1 gene. It is part of a checkpoint complex that responds to DNA damage and arrests the cell cycle. This complex consists of HUS1, RAD9, and RAD1. Upon DNA damage, the complex binds to chromatin, which is dependent on the activation of the ATM kinase. This binding is an early checkpoint signaling event. In somatic cells, the 9-1-1 complex promotes DNA repair. In meiosis, it is crucial for checkpoint function and efficient recombination. In mammals, the 9-1-1 complex helps with homologous chromosome synapsis, double-strand break repair, and cell cycle checkpoint signaling.

HUS1 is a component of the 9-1-1 complex, which is crucial for DNA repair. It acts as a platform on DNA for proteins involved in long-patch base excision repair (LP-BER). This complex stimulates DNA polymerase beta (POLB) activity, stabilizes POLB at LP-BER sites, enhances FEN1 cleavage activity on various substrates, and promotes LIG1 activity during LP-BER. The 9-1-1 complex is essential for the recruitment of RHNO1 to double-stranded breaks (DSB) during the S phase.

HUS1 is also known as hHUS1.

Associated Diseases

WES Whole Exome Sequencing