HTR7

Description

The HTR7 (5-hydroxytryptamine receptor 7) is a protein-coding gene located on chromosome 10.

The 5-HT7 receptor is a member of the GPCR superfamily of cell surface receptors activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). It is coupled to Gs, which stimulates cAMP production, and is expressed in various tissues, notably the brain, gastrointestinal tract, and blood vessels. This receptor is a potential drug target for several clinical disorders. The HTR7 gene encodes the 5-HT7 receptor and produces 3 different splice variants. When activated by serotonin, the 5-HT7 receptor triggers a cascade of events starting with the release of the stimulatory G protein Gs from the GPCR complex. Gs activates adenylate cyclase, increasing intracellular cAMP levels. This receptor plays a role in smooth muscle relaxation in the vasculature and gastrointestinal tract. It is densely concentrated in the thalamus and hypothalamus and is also present at high levels in the hippocampus and cortex. The 5-HT7 receptor is involved in thermoregulation, circadian rhythm, learning and memory, and sleep. Peripheral 5-HT7 receptors are located in enteric nerves, with high levels of 5-HT7 receptor-expressing mucosal nerve fibers observed in the colon of patients with irritable bowel syndrome. A crucial role of the 5-HT7 receptor in intestinal hyperalgesia has been demonstrated in mouse models with visceral hypersensitivity, where a novel 5-HT7 receptor antagonist administered orally reduced intestinal pain levels.

HTR7 is also known as 5-HT7.

Associated Diseases

• schizophrenia
• depressive disorder
• multiple sclerosis
• Parkinson disease
• Alzheimer disease
• lysosomal storage disease