HTR6
Description
The HTR6 (5-hydroxytryptamine receptor 6) is a protein-coding gene located on chromosome 1.
The HTR6 gene encodes the 5HT6 receptor, a subtype of 5HT receptor that binds serotonin (5-hydroxytryptamine, 5HT). It is a G protein-coupled receptor (GPCR) coupled to Gs and mediates excitatory neurotransmission. The 5HT6 receptor is expressed predominantly in the brain, including areas such as the olfactory tubercle, cerebral cortex, nucleus accumbens, striatum, caudate nucleus, hippocampus, and the molecular layer of the cerebellum. Its abundance in extrapyramidal, limbic, and cortical regions suggests a role in motor control, emotionality, cognition, and memory. Blockade of central 5HT6 receptors increases glutamatergic and cholinergic neurotransmission while activating GABAergic signaling. Antagonism of 5HT6 receptors also facilitates dopamine and norepinephrine release in the frontal cortex, while stimulation has the opposite effect. Despite its excitatory action, the 5HT6 receptor is largely co-localized with GABAergic neurons, leading to an overall inhibition of brain activity. 5HT6 antagonists are hypothesized to improve cognition, learning, and memory.
The HTR6 gene encodes for the 5-hydroxytryptamine receptor 6 (5-HT6), also known as Serotonin receptor 6, which is a G protein-coupled receptor that activates adenylate cyclase. This receptor has a high affinity for tricyclic psychotropic drugs. It plays a role in regulating the migration of pyramidal neurons during corticogenesis through the regulation of CDK5 activity. It also acts as an activator of TOR signaling by interacting with MTOR, RPTOR, and NF1.
HTR6 is also known as 5-HT6, 5-HT6R.
